What is Nephroblastoma?

Nephroblastoma, also called Wilms tumor, is a malignant solid tumor found in the kidneys.

Nephroblastoma occurs with the degeneration of the primitive tissue in the womb. It often occurs in the primary cells of the kidney tissue, but can also occur on muscle, tissue, and cartilage.

The worst characteristic of this disease is that the tumors grow quickly and easily form sibling tumors. In fact, sibling tumors are detected in 15% of patients at the time of diagnosis. Sibling tumors (metastases) usually occur in the lung, liver and lymph nodes.

Nephroblastoma (Wilms tumor) can occur in a single kidney or in both kidneys.


Causes of Nephroblastoma

The cause of the disease is not known exactly. However, it is known that changes in genes and chromosomes are effective in the development of the disease. Changes in genes cause impaired development in the kidney and the probability of developing nephroblastoma increases.

In addition, several syndromes that predispose to cancer are known to cause Wilms tumors (nephroblastoma).

  • WAGR syndrome
  • Beckwith Widemann syndrome
  • Denys Drash syndrome
  • Perlman syndrome


Hereditary predispositions are also known to increase the risk of Wilms tumor. If there is Nephroblastoma in the family history, the probability of the child getting it increases.


Nephroblastoma Symptoms

There is no specific symptom of the disease, it is usually noticed during examination or during x-ray and ultrasound taken for other reasons.

Common symptoms in nephroblastoma patients include:

  • Stomach ache
  • digestive disorder
  • bloody urine
  • weight loss
  • Hypertension

(If sibling tumors (metastases) have occurred, symptoms related to lung, lymph and liver organs are also seen)